Symbol
Name
ID

Zbtb18
zinc finger and BTB domain containing 18
MGI:1353609

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Choroid plexus cyst

Agenesis of corpus callosum

Absent speech

Delayed speech and language development

Bruxism

Stereotypical hand wringing

Intellectual disability

Intellectual disability, severe

Developmental regression

Global developmental delay

Seizure

Generalized non-motor (absence) seizure

Disease(s) Associated with ZBTB18

autosomal dominant intellectual developmental disorder 22

Mouse Phenotypes

increased neuron apoptosis

abnormal neuron differentiation

abnormal axon extension

abnormal radial glial cell morphology

abnormal neuronal migration

abnormal neuronal precursor proliferation

abnormal cortical ventricular zone morphology

abnormal subplate morphology

abnormal cerebellar foliation

decreased brain size

enlarged brain ventricles

absent corpus callosum

abnormal hippocampus morphology

abnormal hippocampus granule cell layer

abnormal hippocampus pyramidal cell layer

small hippocampus

abnormal cerebral cortex morphology

abnormal neocortex morphology

abnormal stratification in cerebral cortex

thin cerebral cortex

abnormal cerebellar cortex morphology

abnormal postnatal subventricular zone morphology

abnormal nervous system development

abnormal axon morphology

increased neuronal precursor cell number

decreased neuron number

abnormal neuron physiology

Availability

Mouse Genotype

Zbtb18^tm1Haok/Zbtb18^tm1Haok

Zbtb18^tm2.1Haok/Zbtb18^tm2.1Haok

Zbtb18^tm1.1Nda/Zbtb18^tm1.1Nda
Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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